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Elevated IGF-1 levels have been linked to enhanced chondrocyte proliferation, cartilage matrix production, and osteoblast differentiationmechanisms that support fracture healing and joint preservation

GLP-1 agonists are also associated with reducing cardiovascular adverse events and MACE by improving ejection fraction, coronary blood flow, and cardiac output.2,3 Tirzepatide (Mounjaro) is a dual receptor agonist for GLP-1 and glucose-dependent insulinotropic polypeptide (GIP)

This reflects the fierce competition for promising new drugs

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In acknowledgment of a likely genetic determinant or susceptibility for many individuals incurring PD, scientific focus should be intensified in discovering the genetic factors related to this condition